Greg Barton

Greg Barton is a Distinguished Professor in the Department of BIO at the University of California, Berkeley. He is also a Department Co-Chair and an Investigator at the Howard Hughes Medical Institute. His research focuses on innate immunity, particularly the function and regulation of Toll-like receptors (TLRs) and their role in pathogen recognition and self/non-self discrimination. Barton's work explores the balance between innate immunity and microbial pathogens, with an emphasis on understanding the mechanisms of immune response and its implications for autoimmune disease. His laboratory investigates various aspects of innate immunity, including the role of innate immune receptors in autoimmune conditions and host-pathogen interactions.

Gregory M. Barton's research focuses on immunology, particularly autoimmunity and host-microbe interactions. His work explores how Toll-like receptors (TLRs) regulate innate and adaptive immune responses, including their role in recognizing microbial and self-nucleic acids. Barton's studies highlight the mechanisms by which TLR signaling pathways, such as those involving MyD88 and TIRAP, mediate inflammation and immune activation. His research also examines the spatial and temporal regulation of TLR expression in the intestinal epithelium and the impact of host-microbe interactions on adaptive immunity. These investigations provide insights into the molecular basis of immune responses and their dysregulation in autoimmune diseases.