Scott R Manalis

Scott R Manalis is an Associate Professor in the Department of Mechanical Engineering at the Massachusetts Institute of Technology. His research focuses on high precision measurement for biological systems. Manalis has contributed to advancements in single cell analysis, microfluidics, and micro- and nanomechanical resonators. His work includes developing noninvasive techniques to measure the stiffness of living cells and exploring the physical and genomic features of cancer cells. He has also invented methods for precise measurement of single-cell growth. Manalis is affiliated with the Department of Biological Engineering and has taught courses on forces and flows in biological systems and instrumentation and measurement for biological systems.

Scott Manalis is a researcher at MIT whose work focuses on the measurement and analysis of biological systems at the single-cell and molecular levels. His research interests include the quantification of biomolecular mass, cell growth, and the mechanical properties of cells. Manalis has developed innovative techniques for measuring single-cell density, mass, and deformability, as well as for detecting biomolecules using nanoscale sensors. His studies explore how microenvironmental factors influence cell behavior, such as in pancreatic cancer, and how cellular processes like cytoplasm dilution contribute to senescence. His work bridges biophysics, bioengineering, and cell biology to advance understanding of cellular dynamics.