Ming Associate Guo

Ming Associate Guo is an Associate Professor in the Department of Mechanical Engineering at the Massachusetts Institute of Technology. His research focuses on Cell Mechanics, Soft Active Matter, Mechanics in Development and Disease, and AI in Biology. His laboratory investigates how physical properties and biological function interact in cellular systems, with applications in health and disease. Guo has developed novel techniques for measuring mechanical properties and cellular forces at the single-cell and multi-cellular levels. His work explores the role of mechanical cues in directing developmental processes and disease prevention. He leads an interdisciplinary team of engineers, biologists, and physicists to understand the physical properties of living cells and their impact on health and disease.

Ming Guo is a mechanical engineering researcher at MIT, focusing on cell mechanics, soft matter, microrheology, cell biophysics, and mechanobiology. His work explores the mechanical properties of cells and their interactions with the extracellular matrix, including cell contraction, stress stiffening, and the role of cytoskeletal components like vimentin and alpha-actinin. Guo's research also investigates how cell volume changes, swelling, and mechanical behavior influence cellular functions such as stem cell fate, cancer progression, and immunotherapy. His studies integrate nanotechnology and biophysics to understand biological systems at the molecular and cellular levels, with applications in cancer treatment, immunotherapy, and bioengineered systems.