Luca Pellegrini

Luca Pellegrini is a Fellow at the University of Cambridge, affiliated with the School of Biological Sciences. His research focuses on genomic stability, DNA replication, DNA repair, multi-protein complexes, and macromolecular interactions. His work explores the structural and functional properties of proteins and protein complexes involved in genome maintenance and replication. Pellegrini utilizes techniques such as cryo-electron microscopy, biophysics, biochemistry, and protein engineering to advance his studies. His research theme encompasses the investigation of protein expression, purification, and interactions within biological systems.

Luca Pellegrini is a researcher in the Department of Biochemistry at the University of Cambridge, specializing in DNA replication and repair, and Structural biology. His work explores the molecular mechanisms underlying DNA recombination, repair, and replication, with a focus on the structural insights into key proteins and complexes involved in these processes. His research includes the structural analysis of RAD51–BRCA2 complexes, the Shieldin complex, and the eukaryotic replisome, shedding light on DNA end-joining, homologous recombination, and the role of proteins such as Ctf4 and Smarcal1. Additionally, his studies on fibroblast growth factor (FGF) signaling and its interaction with heparin and heparan sulfate provide structural insights into signaling mechanisms. His research has significant implications for understanding DNA repair pathways and their relevance to cancer biology.