Ole Paulsen

Ole Paulsen is a Fellow at the University of Cambridge, affiliated with the School of Biological Sciences and the Department of Physiology, Development and Neuroscience. His research focuses on neuroscience, particularly the mammalian brain, with an emphasis on circuit mechanisms, plasticity, and synaptic receptors. Paulsen investigates how network oscillations influence spike timing and synaptic plasticity, including spike timing-dependent plasticity (STDP), which is relevant to neural development, learning, and memory. His work employs techniques such as whole-cell recording, multielectrode recording, optogenetics, and miniscope 2P imaging. Research themes include neurodevelopmental disorders and dementia.

Ole Paulsen is a neuroscientist at the University of Cambridge, specializing in the study of neuronal activity and network oscillations in the hippocampus. His research explores the role of GABAergic interneurons, cholinergic modulation, and NMDA receptors in shaping hippocampal dynamics. He investigates how synaptic plasticity and network oscillations contribute to memory encoding and retrieval. His work also examines the impact of neuromodulators like dopamine and the effects of drugs such as ketamine on neural function. Paulsen's research integrates electrophysiological recordings, computational modeling, and in vitro experiments to uncover the mechanisms underlying hippocampal activity and its implications for cognitive processes.