Stephen Graham

Stephen Graham is a Fellow at the University of Cambridge, affiliated with the School of Biological Sciences. His research focuses on the molecular mechanisms viruses use to invade host cells, establish infections, and evade immune defenses. His work encompasses virology, structural biology, host-pathogen interactions, membrane trafficking, and innate immunity. He employs techniques such as X-ray crystallography, electron microscopy, and biophysics to study these processes. Graham's research themes include infection and immune evasion, with an emphasis on understanding how viruses interact with host systems.

Stephen Graham is a researcher in virology, membrane trafficking, structural biology, and biophysics. His work explores the molecular mechanisms of viral entry, replication, and immune evasion, with a focus on alphaherpesviruses, SARS-CoV-2, and vaccinia virus. He investigates how viral proteins interact with host cellular machinery, such as clathrin-mediated endocytosis and the NF-κB pathway, to facilitate infection and subvert immune responses. His structural studies provide insights into viral protein function and disease mechanisms, including the role of RNase H and the evolution of complex viruses. Graham's research bridges structural biology and virology to advance understanding of viral pathogenesis and therapeutic targets.