Regular biography
David Fernandez-Antoran is a Fellow at the University of Cambridge, affiliated with the School of Biological Sciences and the Gurdon Institute. His research focuses on cancer development, ionising radiation, cell competition, 3D cultures, somatic mutations, and cell behaviour. He investigates how radiotherapy influences cell competition outcomes, impacting normal tissue behaviour and tumour development and evolution. His work employs techniques such as confocal microscopy, long-term primary 3D cultures, DNA sequencing, mathematical modelling, and in vivo cell tracing. His research themes include the effects of radiotherapy on normal tissues and in vitro drug screenings.
Scholar-generated biography
David Fernandez-Antoran is a researcher at IIS Aragon and Group Leader at The Gurdon Institute, University of Cambridge. His work focuses on understanding the mechanisms by which normal cells outcompete and eliminate tumour-initiating cells in the context of cancer. His research explores the role of somatic mutations, cell competition, and the impact of ionising radiation in tumour development. He investigates how 3D cultures can model clonal expansion and tumour progression in tissues such as the esophagus and skin. His studies highlight the interplay between genetic mutations and metabolic processes in cancer initiation and progression.