Colin Crump

Colin Crump is a Fellow at the University of Cambridge, affiliated with the School of Biological Sciences and the Department of Pathology. His research focuses on the assembly and egress of viruses, particularly examining the cellular mechanisms utilized and modified by viruses during replication. His work primarily targets two families of important human pathogens: herpesviruses and polyomaviruses. Research areas include cell biology, virology, virus-cell interactions, imaging viruses, virus assembly and egress, and virus immune evasion. Techniques employed involve high-resolution cell and virus imaging, proteomics, virus reverse genetics, cell line forward genetic screens, and protein-protein interactions.

Dr Colin Crump is a Professor of Molecular Virology at the University of Cambridge, specializing in the molecular mechanisms of viral infection and host-virus interactions. His research focuses on alphaherpesviruses, particularly herpes simplex virus type 1 (HSV-1), and explores how these viruses manipulate host cellular processes to facilitate replication, assembly, and egress. His work investigates the roles of host factors such as ESCRT-III, Vps4, and Rab GTPases in viral budding and release. Additionally, he examines the functions of viral proteins like glycoprotein M and tegument proteins in modulating host cell trafficking and immune evasion. His studies also highlight the importance of PACS-1 and PACS-2 in viral pathogenesis and cellular signaling.