Regular biography
Rosana Collepardo-Guevara is a Fellow at the University of Cambridge, affiliated with the School of Biological Sciences. Her research focuses on biomolecular phase separation, biomolecular condensates, chromatin organization, and liquid-like genome organization. She develops realistic multiscale models to uncover the molecular and biophysical mechanisms governing the functional self-organization of molecules within cells. Her current work emphasizes the study of liquid-like chromatin organization. Collepardo-Guevara's research integrates computational and molecular biophysics, with an emphasis on techniques such as multiscale modelling, atomistic simulations, and coarse-grained simulations.
Scholar-generated biography
Rosana Collepardo-Guevara is a Professor of Computational and Molecular Biophysics at the University of Cambridge, specializing in molecular modelling and simulations. Her research focuses on understanding liquid-liquid phase separation and chromatin structure through computational methods. She investigates how physical interactions govern biomolecular condensates, including the role of hydrophobic and non-ionic forces in stabilizing protein condensates. Collepardo-Guevara also explores chromatin dynamics, such as nucleosome plasticity and chromatin fiber polymorphism, to elucidate the impact of epigenetic modifications on chromatin organization. Her work bridges molecular simulations with biological systems, offering insights into the thermodynamics and kinetics of phase separation in complex biomolecular environments.