Ian Brierley

Ian Brierley is a Fellow at the University of Cambridge, affiliated with the School of Biological Sciences. His research focuses on the regulation of virus gene expression during protein synthesis, with particular emphasis on ribosomal frameshifting. His work explores RNA structure, virology, translational control, and related mechanisms. Brierley's research interests include the study of protein synthesis, RNA structure, virology, and translational control. His research also involves techniques such as in vitro translation, RNA structure probing, ribosome profiling, RNA sequencing, and cryoEM. His profile page provides further details on his research areas and themes.

Professor Ian Brierley at the University of Cambridge focuses on translational control, RNA structure, and virus gene expression. His research explores mechanisms of ribosomal frameshifting, particularly in coronaviruses, and the role of RNA pseudoknots in programmed frameshifting. He investigates how viral RNAs manipulate host translation machinery to ensure efficient gene expression. His work also includes the study of non-canonical translation in RNA viruses and the impact of RNA structure on gene regulation. Additionally, he examines the function of RNA thermoswitches and ribosomal pausing during translation. His research contributes to understanding viral replication strategies and their implications for therapeutic interventions.