Regular biography
Johannes Bargehr is a Fellow at the University of Cambridge, affiliated with the School of Biological Sciences. His research focuses on regenerative medicine, cardiac repair, remuscularisation, immunomodulation, and hypoimmune cardiac cell therapy. Bargehr aims to optimise human stem cell-based heart repair and translate his scientific findings into clinical therapies for patients with ischaemic heart disease. His work involves techniques such as tissue culture, immunohistochemistry, spatial transcriptomics, and ex vivo heart perfusion. He collaborates on areas including cardiac immunology, transplant immunology, and tissue repair.
Scholar-generated biography
Johannes Bargehr is a Group Leader in Stem Cell Science at the University of Cambridge, focusing on Regenerative Medicine, Cardiac Repair, Cardiovascular Research, and Stem Cell Biology. His research explores the potential of stem cell-derived tissues for repairing damaged organs, particularly in the context of cardiac and liver diseases. Key studies include the use of cholangiocyte organoids for bile duct repair, the role of FXR inhibition in reducing SARS-CoV-2 infection, and the impact of epicardial cells on heart regeneration. His work also addresses cardiovascular complications in transplant recipients and the effects of proinflammatory cytokines in COVID-19.