Regular biography
Ivanhoe Leung is a professor at The University of Melbourne, affiliated with the CHEM department. His title or rank includes Enzymology, Biological Chemistry, Biophysical Chemistry, and Structural biology Parkville. He is associated with the university's research initiatives, though specific research areas and achievements are not detailed in the provided information.
Scholar-generated biography
Ivanhoe Leung is a researcher at The University of Melbourne specializing in Biological Chemistry. His work focuses on understanding the molecular mechanisms of enzymes involved in oxygen-dependent reactions, particularly 2-oxoglutarate oxygenases. Leung's research explores how these enzymes are inhibited by oncometabolites like 2-hydroxyglutarate and how such inhibition affects histone demethylases. He also investigates the structural and functional properties of hypoxia-inducible factor (HIF) prolyl hydroxylases and their role in cellular oxygen sensing. His studies include the development of inhibitors for therapeutic applications, such as targeting MCR-1 for polymyxin resistance and isocitrate lyase for tuberculosis treatment. Leung's work bridges enzymology, structural biology, and drug discovery.