Dr Francesco Aprile

Dr Francesco Aprile is a researcher affiliated with the Department of CHEM at Imperial College London. His research focuses on Chemical Biology, Biophysics, Antibody Discovery, and Protein Aggregation. Dr Aprile's work explores the intersection of these fields to advance scientific understanding. His profile page provides additional details about his research and contributions. For more information, visit his official website.

Francesco Antonio Aprile is a researcher in the Department of Chemistry at Imperial College London, focusing on the structural and functional characterization of protein misfolding and aggregation processes. His work explores the formation and toxicity of pathological protein aggregates, such as α-synuclein and Aβ42, which are implicated in neurodegenerative diseases. Aprile's research includes the development of methods to study protein dynamics, including the CamSol method for enhancing solubility and rational design of antibodies targeting specific epitopes. His studies also investigate small-molecule inhibitors and the role of molecular chaperones in suppressing aggregation. These efforts aim to uncover mechanisms of toxicity and identify therapeutic strategies for diseases like Alzheimer’s and Parkinson’s.