John McKinney

John McKinney is a Full Professor in the BIO department at École Polytechnique Fédérale de Lausanne. His research focuses on the mechanistic basis of Mycobacterium tuberculosis persistence in the context of host immunity and antimicrobial therapy. His work covers four areas: counter-immunity, in vivo metabolism, antibiotic tolerance, and cell cycle dynamics. His laboratory uses molecular genetics, tissue culture, animal infection models, computational modeling, and other techniques to study these topics. McKinney received his Ph.D. from The Rockefeller University in 1994 and later established his own laboratory at EPFL, where he is also Head of the Laboratory of Microbiology and Microsystems.

John McKinney is a Professor at the Swiss Federal Institute of Technological Lausanne (EPFL) specializing in Microbiology and Microtechnology. His research focuses on the mechanisms of Mycobacterium tuberculosis persistence, drug tolerance, and virulence. McKinney's work explores how metabolic pathways, such as the glyoxylate shunt and methylcitrate cycle, contribute to bacterial survival within host cells and during infection. He investigates the role of stress responses, immune interactions, and metabolic adaptations in tuberculosis pathogenesis. His studies also examine the structural and functional basis of drug targets, such as isocitrate lyase and benzothiazinone-mediated killing. McKinney's research has significant implications for the development of new antimicrobial strategies against tuberculosis.