Hilal Lashuel

Hilal Lashuel is a Professor Emeritus at École Polytechnique Fédérale de Lausanne (EPFL), affiliated with the BIO department. His research focuses on understanding the molecular and structural basis of protein misfolding and self-assembly, particularly in the context of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. His work explores the mechanisms of amyloid-β and α-synuclein aggregation and toxicity, as well as the development of chemical tools to monitor and control protein misfolding. Lashuel has held various academic and research positions, including Assistant Professor at EPFL and Visiting Professor at Stanford University. His research is supported by multiple funding agencies and collaborations with pharmaceutical and biotech companies.

Hilal A. Lashuel's research focuses on the molecular mechanisms underlying neurodegenerative diseases, particularly Parkinson's disease, with an emphasis on α-synuclein and its role in protein aggregation and toxicity. Her work explores the structural dynamics of α-synuclein, its interactions with membranes, and the impact of post-translational modifications on its function. She investigates how these processes contribute to the formation of Lewy bodies and the progression of neurodegeneration. Her research also extends to amyloid formation, including the study of amyloid-β aggregates and their effects on neuronal viability. By combining biophysics, chemistry, and chemical biology, she aims to identify therapeutic targets for neurodegenerative disorders.